Again another easy safe task. No notable safe spots due to spiders aggression and spread in the dungeon. They hit hard for their level and if you are a fresh account I would look at killing spiders elsewhere in the wild.
The Escape route is self explanatory run south. There is nothing else you can really do. It’s a short run, and thugs are aggressive so chances are you are safe. There are level 2 giant spiders by the runes if that is something for you. But it is far out, and the only good escape is the GWD agility shortcut. If you have to kill these spiders you most likely do not have the requirements to use the shortcut.